Sarah Anne Wayne Callies (born June 1, 1977) is an American actress, best known for her roles as Sara Tancredi in the television series Prison Break and Lori Grimes in The Walking Dead.

Callies was born in La Grange, Illinois to Valerie (née Wayne) and David L. Callies, both of whom are professors at the University of Hawaii, Manoa. Her family moved to Honolulu, Hawaii when she was one. She is German and Czech on her father's side.