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[http://en.wikipedia.org/wiki/Indian_massacre_of_1622
The Indian Massacre of 1622 took place in the English Colony of Virginia, in what now belongs to the United States, on Friday, 22 March 1622, Captain John Smith, though he had not been in Virginia since 1609 and was not a firsthand eyewitness, related in his History of Virginia that his braves of the Powhatan Confederacy "came unarmed into our houses with deer, turkeys, fish, fruits, and other provisions to sell us". The Powhatan grabbed any tools available and killed all English settlers they found, including men, women and children of all ages. Chief Opechancanough led a coordinated series of surprise attacks of the Powhatan Confederacy that killed 347 people, a quarter of the English population of Jamestown.
Although Jamestown was spared due to a timely last-minute warning, the Powhatan also attacked and destroyed many smaller settlements along the James River. In addition to killing settlers, the Powhatan burned houses and crops. The English abandoned many of the smaller settlements after the attacks.